Therapeutic effects of nitroglycerin on pregnancy induced hypertension
- VernacularTitle:硝酸甘油用于妊娠高血压综合征治疗的研究
- Author:
Hongbin XU
;
Hongli XU
;
Dilin CHEN
- Publication Type:Journal Article
- Keywords:
Pregnancy complication, cardiovascular;
Hypertension;
Nitroglycerin;
Nitricoxide synthase;
Immunohistochemistry;
Platelet aggregation
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects and possibility of nitroglycerin on Pregnancy induced hypertension (PIH) treatment Methods In comparision with the third trimester normal pregnant women (Normal group) (n=11), 34 moderate/severe PIH cases were divided into three groups: PIH treated only with magnesium sulfate (Mg group) (n=11); PIH treated only with nitroglycerin (Ng group) (n=11); and PIH treated with Mg+ Ng (Combination group) (n=12). The endothelial nitric oxide synthase (eNOS) in placenta was investigatd immunohistochemiscally and quantitatively. Data such as platelet aggregation (PAg), umbilcal artery of S/D ratio and resistance index (RI) with color Doppler and the effect of decrement of blood pressure on PHI groups were evaluated. Results In comparision with Normal group, (1) the quantity of eNOS of PIH cases was signaficently lower (P
