The relation of p53, microvessel density, and vascular endothelial growth factor expression in human colon cancer
- VernacularTitle:结肠癌血管内皮生长因子与微血管密度和p53的关系
- Author:
Shishun ZHONG
;
Zhenshu ZHANG
;
Shumei LI
- Publication Type:Journal Article
- Keywords:
Colon carcinoma;
Vascular endothelial growth factor;
Microvessel density;
p53 gene
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in colon cancer and its relation with the microvessel density (MVD) and p53 gene. Methods The expression of VEGF, p53 gene and MVD of different region of colon cancer were studied by immunohistochemical method from 68 by surgical resected specimens. Results The positive rates of VEGF, p53 and MVD in colon cancer were significantly higher than those in peritumor and normal tissue. The expression of VEGF and p53 positively correlated with depth of invasion, lymph node metastasis, distant metastasis, vessel invasion and Dukes' stage, but their relation to the histologic types was not significant. The MVD in p53(+) ( 34.6 ?12.2 ) and VEGF(+) (31.2?12.6) tumors was significantly higher than that in p53(-) and VEGF(-) tumors (15.0?7.9; 12.7?6.3, respectively, P
