Anticoagulant and Fibrinolytic Mechanism of VascularEndothelial Cells in Blood Stasis Syndrome
- VernacularTitle:血瘀证血管内皮细胞损伤的抗凝与纤溶障碍研究
- Author:
Qi WANG
;
Yunbo CHEN
;
Shilong LAI
;
Weixiong LIANG
;
Zehuai WEN
;
Shuyi CHENG
- Publication Type:Journal Article
- Keywords:
BLOOD STASIS/pathophysiology;
ENDOTHELIUM, VASCULAR;
CELL CULTURE;
ANTITHROMBIN Ⅲ /blood;
ALTEPLASE/blood;
PLASMINOG EN ACTIVATOR INHIBITOR/blood;
DISEASE MODELS, ANIMAL;
RABBITS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anticoagulant and fibrinolytic mechanism of vascular endothelial cells in rabbit model of blood stasis syndrome (BSS). Methods BS S rabbit model was induced by injection of noradrenaline and bovine serum albumin . The aortic endothelial cells from the normal rabbits (Group A)and BSS rabbits (Group B)were cultured primarily and subcultured. The activities of antithrombin Ⅲ (AT_Ⅲ), tis sue_type plasminogen activator (t_PA) and plasminogen activator inhibitor (PAI) in the plasma of rabbits and cultured supernatant were measured. Results The activities of t_PA and AT_Ⅲ were obviously decreased and PAI activity incre ased in the plasma of BSS model rabbits as compared with those of the normal rabbits (P 0.05 ). Conclusion Anticoagulant and fibrinolytic dysfunction p lays an imp ortant role in the occurrence and development of BSS.
