Preventive Effects of Radix et Rhizoma Rhei Granule on the Occurrence ofComplicated Stress Ulcer of Stomach in Rats After Cerebral Infarction

VernacularTitle:大黄胶囊预防脑梗塞并发应激性胃溃疡的实验研究
Author: Mingyi TAN ; Gencheng CHEN ; Chunzh TANG
Publication Type:Journal Article
Keywords: CEREBRAL INFARCTION/complications; STOMACH ULCER/TCD therapy; RADIX ET RHIZOMA RHEI GRANULE/pharmacology; RHEUM OFFICINALE /ther .use; DISEASE MODELS, ANIMAL; RATS
From: Journal of Guangzhou University of Traditional Chinese Medicine 1999;0(02):-
CountryChina
Language:Chinese
Abstract: Objective To explore the preventive effects of Radix et Rhizoma Rhei Granule on the occurrence of complicated stress ulcer of stomach (CSUS) in rats after cerebral infarction (CI) and its mechanism. Methods Rat models wi t h CI were established by the occlusion of middle cerebral artery. Preventive tre at ment of CSUS in rats after CI with Radix et Rhizoma Rhei Granule was carried out . Results As compared with the control group (Group A),apoptosis index of gastric mucosal cells was decreased and prolifer ation index increased, 5_HT level and noradrenaline (NE) content in gastric muco sa and plasma were declined, gastric and cholic acid reduced and pH value incre a sed in gastric juice of the treatment group(Group B) (P