Effects of Oral Administration and Intraperitoneal Injection of Total Polysaccharide of Sijunzi Decoction on Mouse Immune Function
- VernacularTitle:四君子汤复方总多糖口服和注射给药对免疫功能影响的对比研究
- Author:
Hua ZHOU
;
Liang LIU
;
Peixun WANG
;
Yinjie HU
;
Lian ZHOU
;
Ruiyan LIANG
;
Liuying CAO
- Publication Type:Journal Article
- Keywords:
Sijunzi decoction/pharmacology;
polysaccharide;
@delayed type hypersensitivity/drug effect;
@hemolysin response/drug effect;
@lymphocytic proliferation/drug effect
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study difference of the immune response between oral administration and intraperitoneal injection of total polysaccharide of Sijunzi decoction (SJTP) in mice. Methods: The immunosuppressed mice model was established by intraperitoneal injection of cyclophosphamide (CY). The effects of SJTP on the weight of immune organs,hemolysin response and delayed type hypersensitivity (DTH) were observed,and the influences on normal mouse spleen lymphocytic proliferation of mice were also studied. Results:SJTP can remarkably counteract the immunosuppression induced by CY, decrease the weight loss immune organs,increase the hemolysin response and DTH,and promote the proliferation of lymphocytes.The effect of oral administration is superior to intrapertoneal injection.Conclusion:SJTP can improve the humoral and cellalar immunity of mice.The immune activities resulting from oral administration of SJTP have some special characteristics,and its possible mechanism is also discussed.
