Protective Effect of Total Peaony Glycoside on Calium-Overloading Injury of Nerve Cells in Rat Cortex
- VernacularTitle:赤芍总苷对大鼠皮层神经细胞钙超载损伤的保护作用
- Author:
Lina HE
;
Subing HE
;
Yi JING
;
Jun YANG
- Publication Type:Journal Article
- Keywords:
@Total peaony glycoside/pharmacology;
Neuron/drug effect;
Neuron/pathology;
@Caliun overloading/induced by chemicals
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the protective effect and mechanism of total peaony glycoside (TPG) on calium overloading injury of nerve cells in rat models. Methods: The nerve cells of cerebral cortex of primary rats were subject to tissue culture,and the calcuim-overloading injury models were induced by caffeine,KCl and NMDA respectively. Results:TPG possessed obvious protective effects on the nerve cells in rat models, increased the number of survival nerve cells and reduced the content of LDH released nerve cells.Conclusion: TPG can protect rat nerve cells with calium-overloading injuriy.
