Effects of ovulation induction on expression of integrins ?_4?_1 in endometrium
- VernacularTitle:自然及促排卵周期子宫内膜整合素?_4?_1的表达
- Author:
Ying WANG
;
Yongjian CHEN
;
Meizhi LI
- Publication Type:Journal Article
- Keywords:
Endometrium;
Integrins;
Ovum implantation;
Ovulation induction;
Receptors, lymphocyte homing
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of clomiphene citrate (CC) and human menopausal gonadotropin (hMG) on the expression of integrins ? 4? 1 during implantation window in endometrium. Methods Endometrium integrin ? 4? 1 expression was detected by immunohistochemistry method in the mid secretory phase of 48 normal natural cycles. CC+hCG or CC+hMG+hCG cycles in 30 polycystic ovary syndrom (PCOS) patients and 48 normal women. Results The expression of endometrial integrin ? 4? 1 was stronger in the natural cycls than those of ovulation induction cycles with CC+hCG or CC+hMG+hCG. So was the pregnancy cycles as compared with the non pregnant cycles. Conclusion The endometrial receptivity in the min luteal phase and pregnant rate declined during ovulation induction by CC+hCG or CC+hMG+hCG in either normal women or PCOS patients.
