Effect of Helicobacter pylori infection on cyclooxygenase-2 expression in gastric antral mucosa
- VernacularTitle:幽门螺杆菌感染对胃黏膜环氧合酶2表达的影响
- Author:
Hong LU
;
Xiaoyu CHEN
;
Wenzhong LIU
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase 2;
Helicobacter pylori;
Chronic gastritis
- From:
Chinese Journal of Digestion
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of H. pylori infection on cyclooxygenase 2 (COX 2) expression in gastric antral mucosa. Methods Antral biopsies were taken from 46 patients with chronic gastritis and H. pylori infection before and after anti H. pylori treatment. COX 2 protein was stained by immunohistochemical method. Gastritis and H. pylori infection status were graded according to the updated. Sydney system. Results Cytoplasmic staining of COX 2 protein could be detected in epithelial cell both before and after eradication of H. pylori . The mean percentage of the cells staining with COX 2 was significantly higher in H. pylori infected mucosa, compared with the mucosa after successful H. pylori eradication [(20.1?13.1)% vs (13.8?5.9)%, P
