Study on the Inclusion Compound of Baicalin with Hydroxypropyl-?-Cyclodextrin
- VernacularTitle:黄芩甙-羟丙基-?-环糊精包合物的研究
- Author:
Wei SHAO
;
Min YUAN
;
Daqing WANG
;
Chunxiang WANG
;
Guangtai MI
- Publication Type:Journal Article
- Keywords:
baicalin;
Hydroxyproply-?-cyclodextrin;
inclusion compund
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare the inclusion compund of baicalin-hydroxypropyl-?-cyclodextrin (HP-?-CD) and identify it. Methods: The inclusion compound of baicalin-HP-?-CD was confirmed by freeze-drying method. Results: The inclusion compound of baicalin-HP-?-CD was confirmed by IR absorption spectroscopy and differential scanning calorimetry (DSC). The results indicated that the inclusion compound of baicalin-HP-?-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of baicalin to HP-?-CD was 1∶1. Conclusion: The solubility of baicalin is increased from 0.112mg/ml to 2.743mg/ml. when the drug is included by HP-?-CD.
