Effects Origin-Preserving Decoction on the Proliferation of Marrow Hematopoietic Cells in Aplastic Anemia (AA)
- VernacularTitle:保元汤对再障小鼠骨髓造血细胞的刺激增殖作用
- Author:
Hong YU
;
Danni ZHU
;
Yongqing YAN
;
Hongjiang XU
- Publication Type:Journal Article
- Keywords:
aplastic anemia;
Origin-Preserving Decoction;
colony culture;
MTT assay;
proliferation
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Origin-Preserving Decoction on the proliferation of marrow hematopoietic cells in aplastic anemia mice. Methods:Based on experimental AA models induced by Benzene and 60Co radiation in mice, the experiments including semi-solid colony culture (CFU-GM、CFU-E、BFU-E) and liquid culture (MTT Assay) were undertaken to investigate the effects of Origin-Preserving Decoction on the proliferation of marrow hematopoietic cells in AA mice. Results:Origin-Preserving Decoction (3g/kg) (ig.) could improve the outputs of CFU-GM, CFU-E and BFU-E in AA mice damaged by benzene and 60Co radiation: MTT assay showed that Origin-Preserving Decoction could stimulate the hematopoeisis of bone marrow of AA mice radiated by 60Co. Conclusions: Origin-Preserving Decoction has a good future for AA therapy.
