Effects of metformin on hyperinsulinemic anovulation
- VernacularTitle:二甲双胍治疗高胰岛素血症所致无排卵的临床观察
- Author:
Ruzhi LI
;
Jinfang LIN
;
Jianping ZHOU
- Publication Type:Journal Article
- Keywords:
Hyperinsulinism;
Anovulation;
Clomiphene;
Metformin
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of metformin on serum testosterone (T)levels and ovulation in hyperinsulinemic women Methods Twenty nine patients with hyperinsulinemic anovulation were treated with metformin for 12 weeks Among them 19 had history of clomiphene(CC) treatment with 11 cases failure CC was given again after one month of metformin treatment Serum T, luteinizing hormone,follicle stimulating hormone, insulin(Ins) levels were measured after 4 weeks of treatment Basic body temprature was also observed Results Serum T and Ins levels declined significantly after 4 weeks of metformin treatment [(2 7?1 6) nmol/L Vs (1 9?1 0) nmol/L, (49 2?34 1) mU/L Vs (25 3?23 9) mU/L, P
