Influence of different dosages of Vi conjugate vaccine (Vi - rEPA) on the immunogenicity in children
- Author:
Dang Duc Anh
- Publication Type:Journal Article
- Keywords:
immunogenicity, Vi – rEPA
- MeSH:
Vaccines;
Typhoid Fever;
child;
blood
- From:Journal of Preventive Medicine
2004;14(6):30-33
- CountryViet Nam
- Language:Vietnamese
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Abstract:
In a double blinded study which was conducted at 3 kindergartens of 3 communes of Thanh Ba district and Phu Tho district showed that the effectiveness of Vi-rEPA for typhoid fever in 2-5 year old children reached to 89% for 46 months. Vi-rEPA containing 25mg of Vi induced more than 8 fold rise of IgG anti-Vi in all vaccines. The dosage immunogenicity study of 5, 12.5 and 25mg of Vi-rEPA was injected 6 weeks apart and blood samples were taken before, 10 weeks and 1 year after the first injection. At 10 weeks, the antibody levels of children with 25 mg injections were higher than that of children with 12.5mg and 5mg injection, and all 3 groups had antibody levels declined 7 folds, but still remained significantly higher than before immunization. This study confirmed the safety and immunogenicity of Vi-rEPA
