Study on association of HLA-DRB1 alleles with gastric carcinoma and Helicobacter pylori infection
- VernacularTitle:人类白细胞抗原-DRB1与胃腺癌及其临床特征和幽门螺杆菌感染的相关性
- Author:
Jun LIN
;
Changsheng DENG
;
Jie SUN
- Publication Type:Journal Article
- Keywords:
HLA;
Sequence analysis,DNA;
Stomach neoplasm;
Helicobacter pylori;
Genetic susceptibility
- From:
Chinese Journal of Digestion
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of HLA DRB1 alleles with gastric carcinoma and H. pylori infection. Methods HLA DRB1 alleles polymorphism in 63 patients with gastric adenocarcinoma and 136 normal controls were tested with the polymerase chain reaction/sequence specific primer(PCR/SSP) technique. The status of H. pylori infection was determined by histology of gastric biopsy specimens and /or by ELISA. Results Both HLA DRB1 0901 and HLA DRB1 12 were positively associated, and HLA DRB1 15 was negatively associated with gastric adenocarcinoma, but no significant associations were found between patients with and without above HLA DRB1 alleles with regard to patients' age at presentation, sex ratio, tumor site (distal vs proximal), TNM staging, histological grading of tumor or status of H. pylori infection. Conclusions Our results suggest that HLA DRB1 0901, DRB1 12 and DRB1 15 are associated with gastric adenocarcinoma, but are not associated with the clinical features of gastric adenocarcinoma and the status of H. pylori infection.
