Effects of Blood-Circulation Promoting and Phlegm Removing Treatment on Mitochondria membrane in Spontaneous Hypertensive Rats
- VernacularTitle:活血祛痰法对自发性高血压大鼠心肌线粒体膜的影响
- Author:
Yi PAN
;
Lili WU
;
Can YAN
;
Weiwe LEI
- Publication Type:Journal Article
- Keywords:
HYPERTENTION/TCD therapy;
EXPECTORANTS (TCD)/ther.use;
BLOOD ACT STASIS REMOV DRUGS/ther. use;
MITOCHONDRIA, HEART/drug eff.;
MEMBRANE LIPIDS;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of blood-circulation promoting and phlegm removing treatment on the structure, activity of Ca 2+ -Mg 2+ ATPase and malondialdehyde(MDA) content of mitochondria membrane in spontaneous hypertensive rats (SHR). Methods Spontaneous hypertensive rats (SHR) were classified into 14-week-old model group(Group C),28-week-old model group(Group D) and treatment group (treated with blood-circulation promoting and phlegm removing Chinese herbal medicine,Group E).Normal Wistar rats 14 weeks old (Group A)and 28 weeks old(Group B) served as the controls.The structure of myocardial mitochondria membrane were analyzed quantitatively by transmission electron microscope,and the activity of Ca 2+ -Mg 2+ ATPase and MDA content were also detected. Results Specific surface area of mitochondria was smaller, the activity of Ca 2+ -Mg 2+ ATPase was lower and MDA content was higher in SHR than the controls.MDA content increased as the duration of disease prolonged. Chinese herbal medicine could counteract the above changes. Conclusion Blood-circulation promoting and phlegm removing herbs can partially counteract the progress of left ventricular hypertrophy in SHR.
