Effects of Jinma Tongluo Capsule on Micronucleus of Mice Marrow Cells
- VernacularTitle:金马通络胶囊对小白鼠骨髓细胞微核的影响
- Author:
Guangli RAO
;
Guilan LI
;
Yungqing GUO
;
Jiangping CHEN
- Publication Type:Journal Article
- Keywords:
JinmaTongluo capsule/toxicity;
Flos Daturae/toxicity;
@rates of micronucleus
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of Jinma Tongluo capsule (JTC) on the incidence of micronucleus of marrow cells in mice with Kunming species were reported. JTC intragastric dosages of 100 mg/kg, 400 mg/kg, 1600 mg/kg (equivalent to 3, 12 and 48 times of the clinical dosage respectively) were given to the mice.Twenty-four hours later the mice were executed and the marrow cells were examined. The incidence of micronucleus was 2.00‰, 1.83‰, 2.17‰ respectively. In the group of dosage of 1600 mg/kg, the incidence was maintained in the normal limits within 12～72h. And the differences were not significant as compared with the negative group and the solvent control group. It's indicated that ig total alkalin of Flos Daturae under 0.86 mg/kg has no effect on micronucleus of mice marrow cells.
