THE DISTRIBUTION OF NOS POSITIVE NEURONS AND FIBERS IN SPINAL INTERMEDIATE GRAY OF SPONTANEOUSLY HYPERTENSIVE RATS
- VernacularTitle:一氧化氮合酶在自发性高血压大鼠脊髓中间带灰质的分布
- Author:
Chengsan SUN
;
Enhua YU
- Publication Type:Journal Article
- Keywords:
Nitric oxide synthase;
Spinal intermediate gray;
Histochemistry;
Spontaneously hypertensive rat
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of nitric oxide synthase (NOS) in the spinal intermediate gray and it's relationship with hypertension. Methods Using NADPH\|d histochemistry method, the distribution of NOS in the spinal intermediate gray was investigated under microscope and analyzed quantitatively with image analysis system. Results 1 NOS positive neurons were observed mainly in the nucleus intermediolateralis thoracolumbalis pars principalis(ILp) and paracentral gray, as well as in the area of nucleus intercalatus spinalis. NOS positive cells existed in groups in ILp. The size and density of NOS positive cell groups differed with different spinal segments, no significant difference could be found in the distribution pattern of NOS positive neurons in the spinal intermediate gray between SHR and WKY. 2 The A value of NOS positive substance in the ILp of SHR was significantly lower than that in WKY. Conclusion The results imply that lower expression of NO in the area of ILp in SHR might be related to the development and maintenance of hypertension in SHR.\;
