RAT P53GENE MUTATIONS IN THE COLORECTAL TUMORS INDUCED BY N-METHYL-N-NITROSOUREA
- VernacularTitle:甲基亚硝基脲引起大鼠大肠肿瘤中p53基因突变
- Author:
Jiahui LI
;
Ailing GAO
;
Songbin FU
;
Pu LI
;
Zhicheng LIU
- Publication Type:Journal Article
- Keywords:
MNU;
Colorectal tumors;
p53gnen mutation
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective We have examined tumor suppressor gene p53 from N- methyl - N- nitrosourea (MNU ) induced the col - orectal tumors in rats. Methods PCR, SSCP and DNA sequence analysis. Results In colorectal tumors induced by MNU, the mobil- ity shifts of p53 gene mutation were observed, p53 gene mutation was a deletion at third position C of codon 244 in exon7. Conclu- sion The present study suggested that MNU induces rat p53 mutations in the colorectal tumors.
