Pharmacodynamic Study of Tongmai Oral Liquid for Chronic Nephritis Rat Model with Qi- deficiency and Blood-stasis Syndrome
- VernacularTitle:通脉口服液对慢性肾炎气虚血瘀证大鼠模型的药效学研究
- Author:
Nizhi YANG
;
Kun BAO
;
Lixing WANG
;
Hua WANG
;
Weiwe LEI
- Publication Type:Journal Article
- Keywords:
TONGMAI ORAL LIQUID/pharmacology;
ASTRAGALUS MEMBRANACEUS/ther. use;
PANAX PSEUDOGINSENG/ther. use;
NEPHRITIS/ TCD therapy;
T-LYMPHOCYTES/immunology;
BLOOD RHEOLOGY/drug effects;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of Tongmai Oral Liquid (TOL) for chronic nephritis rat model with Qi-deficiency and blood-stasis syndrome was studied.The model was established by adding Qi-deficiency and blood-stasis syndrome to the chronic nephritis rats. The experimental rats were randomly allocated to 5 groups: Group A (treated with high dosage of TOL), Group B (treated with low dosage of TOL), Group C (treated with Jinshuibao), Group D (model control group) and Group E (normal control group). After 4 weeks of treatment, general health state, biochemical indexes including T lymphocyte subgroup and blood rheology, and pathological damage of kidney tissue were much improved in Group A than Group B and Group C. It is indicated that TOL can improve the renal function and delay the occurrence of glomerular arteriosclerosis in rats by reinforcing Qi, activating blood flow, regulating immune function, lessening the hypercoagulative state and reducing renal damage.
