Effects of Insulin-like Growth Factor-Ⅰ and Insulin-like Growth Factor Binding-protein 1 on Development of Ovarian Follicles during Superovulation Cycle
- VernacularTitle:胰岛素样生长因子Ⅰ及其结合蛋白1对超排卵周期卵泡发育的影响
- Author:
Danqing CHEN
;
Yifu SHI
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor Ⅰ;
*" Insulin-like growth factor binding protein 1;
*" Superovulation
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of insulin-like growth factor Ⅰ (IGF-Ⅰ) and insulin-like growth factor binding-protein 1 (IGFBP-1) on development of ovarian follicles during gonadotropin stimulation in in-vitro fertilization (IVF) program. Methods Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay were used to determine the levels of IGF-Ⅰ, IGFBP-1 and estradiol (E 2) in serum and follicular fluid obtained during oocyte pick-up (OPU) in 32 IVF-embryo transfer cycles. Results (1) Serum IGFBP-1 levels increased with growth of follicles [(3 5?1 0) ?g/L during OPU, (2 1?0 5) ?g/L before stimulation, P 0 05]. Significant positive correlation was found between serum IGFBP-1 and serum E 2 [(3 5?1 0) ?g/L, (3 293? 1 361) pmol/L, r =0 41, P
