Effects of Epimedium on the Expression of Interleukin-6 Messenger Ribonucleic Acid in Bone of Ovariectomized Rat
- VernacularTitle:淫羊藿对去卵巢大鼠骨组织白细胞介素6mRNA表达的影响
- Author:
Baoli WANG
;
Jinxing QUAN
;
Shanyi GUO
- Publication Type:Journal Article
- Keywords:
Epimedium brevicornum;
*"Ovariectomy;
*"Interleukin-6;
*"RNA, messenger
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the traditional herb-epimedium on the expression of interleukin-6 (IL-6) mRNA in bone of ovariectomized rat. Methods Forty female rats were randomly allocated into 4 groups, 10 in each: ovariectomized (OVX) group, sham operation group, OVX followed by epimedium (group 3)or nilestriol (group 4) for 3 months respectively. All rats were then sacrificed,and total RNA were directly isolated from their right tibia. Interleukin-6 mRNA expression was detected by relative semiquantitative reverse transcription-polymerase chain reaction technique. Lumbar bone mineral density (BMD) was measured by dual-energy X ray absorptiometry before sacrifice. Results The BMD of epimedium group was significantly higher than that in the OVX group ( P
