Mechanism of metronidazole resistance of Helicobacter pylori
- VernacularTitle:幽门螺杆菌对甲硝唑耐药机制的探讨
- Author:
Kui JIANG
;
Jianzhong ZHANG
;
Guozong PAN
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Metronidazole;
Antibiotic resista
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the mechanism of metronidazole resistance to Helicobacter pylori (Hp). Methods (1) The selective pressure test of metronidazole. (2) SDSPAGE electrophoresis. (3) Nitrate reduction test. (4) Test for detecting the enzyme activities associated with 95 substrates of gram negative. Results After the mutation of Hp from sensitive to resistant strains, the activities of enzymes associated with monomethyl succinate, succinic acid and Dalanine is decreased, and those associated with Lfucose 6phosphate glucose is increased. Conclusions The metronidazole resistance of Hp is associated with the metabolism and the change of enzyme activities.
