Long-term Effects of Low-dose Combined Norethisterone and Combined 18-metayl-Norethisterone on Lipid Metabolism in Healthy Women
- VernacularTitle:连续服用低剂量复方炔诺酮与复方18-甲基炔诺酮对妇女脂质代谢的远期影响
- Author:
Ying LI
;
Guanghua DONG
;
Yulin WU
- Publication Type:Journal Article
- Keywords:
Norethindrone;
Norgestrel;
Lip
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the long term effects of combined oral contraceptive pills use on the mean of serum TG, TC, HDL C, LDL C, ApoA1, ApoB and Lp(a). Methods The study was carried out in 446 women grouped as combined norethisterone containing ethinylestradiol (EE) 35 ?g and norethisterone 625 ?g; combined 18 metayl norethisterone (norgestrel) containing EE 30 ?g and 18 metayl norethisterone 300 ?g for using 5～25 years, and control subjects wearing IUD for the corresponding period. The three groups were similar in age, body mass index (BMI), continued period of contraceptives use and income. Results The data showed that changes of varying degree of lipid and lipoprotein parameters were obvious in women of long term taking low dose combined norethisterone and norgestrel, compared with the control. The mean of TG, HDL C, ApoA1 were significantly increased simultaneously ( P
