Effects of the Combination of Shenmai Injection and Aminophylline on Diaphragmatic Function in Rabbits
- VernacularTitle:参麦注射液与氨茶碱合用对家兔膈肌功能的影响
- Author:
Sudong GUAN
;
Guilan LIU
;
Min GE
- Publication Type:Journal Article
- Keywords:
@Shenmai Injection /pharmacology Aminophylline /pharmacology Trans-mem- brane potentials /drug effects;
Evoked potentials /drug effects;
Electromyography/ drug effects;
Drug therapy, combination
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Effects of Shenmai injection and aminophylline alone or in combination on transdiaphragmatic pressure and electrical activity of diaphragm were observed, so as to evaluate their effecfs on diaphragmatic fatigue. Methods: The diaphramatic fatique (DiF) model was estab- lished by stimulating bilateral phrenic nerves for 40 minutes. The animals were allocated to three groups: Shenmai group (2mL/kg, N=7), aminophylline group (20mg/kg, N=7) and combi- nation group (Shenmai injection 2mL/kg+aminophylline 20mg/kg, N=7) The transdi- aphragmatic pressure (Pdi) and diaphragmatic electromyogram (EMGdi) were recorded before and after treatment. EMGdi was analysed by computer and then the high/low frequency ratio (H/L) and the central frequency (Fc) were caculated. The diaphragm evoked potential (DEP) was record- ed simutaneously. All data was analysed by analysis of variance and q test. Results: Pdi, H/L, Fc and amplitude of DEP were markedly increased after the treatment with aminophyline and Shen- mai injection alone (Compared with DiF. P
