Effects of Niaodukang on Lipid Metabolism in the Rat Modelwith Chronic Renal Failure
- VernacularTitle:尿毒康对慢性肾功能衰竭大鼠模型脂质代谢的影响
- Author:
Daji XU
;
Nizhi YANC
- Publication Type:Journal Article
- Keywords:
@NIAODUKANG /pharmacology;
KIDNEY FAILURE, CHRONIC/TCD therapy;
REINFORCING SPLEEN & KIDNEY;
ACTIVATING BLOOD;
TRIGLYCERIDES/blood;
CHOLESTEROL/blood;
CARRIER PROTEINS;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Niaodukang is an effective formula used in the second affiliated hospithal of Guangzhou Universityof TCM for chronic renal failure, which is composed of Rhizoma Rhei,Radix Polygoni Multiflori,Radix Astragali seu Hedysari and Fructus Ligustri Lucidi with the actions of supplementing qi, warmingYang, strengthening spleen, tonifying kidney, promoting blood circulation and removing turbid pathogenicfactor. To explore the effect of Niaodukang on the lipid metabolism of chronic renal faiure, rat model wasset up with improved technique of 5/6 kidney mass removal. After the accomplishment of the rat model for2 weeks, the models matched with the geneal conditions and 24 hours' proteinuria were randomly allocated to five groups: the model group,two Niaodukang groups with high and low dosages respectively, CoatedAldehyde Oxystarch group and the nounal control group. Serum contents of triglyceride, cholesterol andapoprotein were tested.The results showed that the blood lipid level in the model group was higher than thenormal group,and decreased markedly after the treatment of Niaodukang. It is indicated that Niaodukang exerts a good effect on the blood-lipid metabolism in rat model with chronic renal failure.
