Relationship between the expression of nm23-H1 and p53 genes and gastrointestinal cancer metastasis
- VernacularTitle:nm23-H1和p53基因表达与胃肠肿瘤转移的关系
- Author:
Wenbin YU
;
Baorui LIU
;
Liwei ZHANG
- Publication Type:Journal Article
- Keywords:
nm23-Hl Gene p53 Stomach neoplasm Colorectal neoplasm Gene expression
- From:
Chinese Journal of Digestion
1996;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
The expression of nm23-H1 and p53 genes were studied with ABC immunohistochemical method in 54 cases of gastric cancer and 57 cases of colorectal cancer. The result showed that the expression of nm23-H1 was 72.2% in gastric cancer and 64.9% in colorectal cancer, respectively. No significant difference was found between the expression of this gene and lymph node metastasis of the cancers. The mutant p53 protein expression was 53.7% and 52.6% in gastric and colorectal cancers, respectively. Although it was not correlated with lymph node metastasis, its expression was significantly higher in cancers with distant metastases, suggesting that the mutant p53 protein expression may be indicative of poor prognosis in gastrointestinal cancers.
