Effects of Panaxatriol Saponins Isolated from Sanchi(Panax pseudo-ginseng var.notoginseng)on Animal Platelet Function and Thrombosis
- VernacularTitle:三七三醇皂甙对动物血小板功能及血栓形成的影响
- Author:
Ya SU
;
Yigui ZHAO
;
Zongpong ZHANG
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Panaxatriol saponin (PTS), isolated from Panax pseudo-ginseng var. notoginseng, 1~ 4mg/ml inhibited rabbit platelet aggregation induced by ADP,collagen and arachidonic acid respectively in vitro. In rat,PTS 75 ~300mg/kg intraduodenally inhibited dose-dependently platelet aggregation induced by these inducers, andalso inhibited platelet thrombonane A2 release induced by collagen,but did not affect the formation of aorticwall PGI2,PTS 50~200mg/kg significantly inhibited experimental thrombosis in rats. These results showed that the anti-thrombosis action of PTS may be due to its inhibitory action on platelet aggregation and TXA2re lease
