Effects of nifedipine and nicardipine on proliferation of human lung fibroblastsand synthesis of collagen and hyaluronic acid
- VernacularTitle:硝苯啶和尼卡地平对人成纤维细胞增殖、胶原与透明质酸合成的作用
- Author:
Xuanhai LI
;
Hailin LIU
;
Hanming LU
- Publication Type:Journal Article
- Keywords:
Mifedipine Nicardipine Collagen Hyaluronic acid Lungfibroblasts
- From:
Chinese Journal of Digestion
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:T0 study the mechanism and the potentiality of calciumchannel blocker to prevent organal fibrogenisis. Materials and Mehods:The effects ofnifedipine(Nif)and nicardipine (Nic)on proliferation of human lung fibroblasts(HLF)and synthesis of coliagen and hyaluronic acid(HA)were determined by means of MTT,measuring the incorporation of 3H-proline and radioimmunoassay, respectively.Results: both Nif and Nic supressed HLF proliferation and collagen synthesis,as wellas decreased the production of HA in a concentration-dependent manner at l0-40?mol/L. In addition,there were no significant toxic actions on HLF. Conclusion: Nifand Nic might be hopeful antifibrotic drugs.
