Studies on the Anti-arrhythmic Effect of Xanthotoxol in Experimental Animals
- VernacularTitle:花椒毒酚抗实验性心律失常作用的研究
- Author:
Qishen LIAN
;
Rende XIANG
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Xanthotoxol (XT) is a coumarin isolated from ethanolic extract of fruits of Cnidium monnieri (L. )Cus son. It is effective not only for the prevention of ventricular fibrillation of mice induced by chloroform or that of rats induced by calcium chloride,but also is effective for the treatment of arrhythmia induced by aconitine in rats. It can raise the threshold of ventricular fibrillation induced by electrical stimulation in rabbits. Fur thermore,XT can inhibit the action potential amplitude of isolated sciatic nerves in toads. These results indi cated that XT possesses antiarrhythmic effects. The iv LD50 of XT in mice is 47.0mg/kg
