Influence of Safflower(Carthamus tinctorius)on Ca~(2+) Transmembrane Influx in Rat Aorta
- VernacularTitle:用~(45)Ca研究红花对大鼠胸主动脉Ca~(2+)内流的影响
- Author:
Shangwu MO
;
Zhiheng CHEN
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Influence of Carthamus tinctorius L. has been studied on Ca2+ transmembrane influx in rat aorta when its extract was used at 5, 50, 500?g/ml. It was shown that the resting 45Ca influx in rat aorta ring was not altered by C. tinctorius but the 45Ca influx evoked by norepinephrine (1.2 x 10-6 mol/L ) and KCl solution (100mmol/L) was inhibited in a concentration-dependent manner. The results demonstrated that the receptor-operated Ca2+ channel (ROC) and potential-dependent Ca2+ channel (PDC) in cell membrane of smooth muscle could be blocked by C.tinetorus as well as by verapamil.
