Effects of Halothane , Enflurane and Isoflurane on Hepatic Function in Children.
10.4097/kjae.1992.25.4.719
- Author:
Seong Deok KIM
1
;
Bong Jin KANG
Author Information
1. Department of Anesthesiology, College of Medicine, Seoul National University, Seoul 110-744, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics;
halothane;
enflurane;
isoflurane;
liver;
hepatic function
- MeSH:
Alanine Transaminase;
Alkaline Phosphatase;
Anesthesia;
Anesthetics;
Aspartate Aminotransferases;
Bilirubin;
Child*;
Enflurane*;
Halothane*;
Humans;
Isoflurane*;
Liver;
Thiopental;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
1992;25(4):719-725
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effects of halothane, enflurane and isoflurane on the postoperative hepatic functions were compared in 91 pediatric patients with normal preoperative hepatic funcions. After induction of anesthesia with thiopental and vecuronium, all the patients were randomly divided into three groups of halothane(n=31), enflurane(n=27) and isoflurane(n=33). Anesthesia was maintained with 1 MAC of each anesthetics combined with N2O(50%) and O2(50%). On the postoperative 1st day(POD#1), we observed elevated total bilirubin in each groups, which was normalized on the postoperative 2nd day(PDO#2). Inthergroup comparisons were not significant. SGOT was elevated on the POD#1, but returned to normal on the POD2 in halothane and isoflurane groups. SGPT showed no changes postoperatively. SGOT and SGPT were not significant between the groups. Alkaline phosphatase showed significant decrease on the POD#2 in enflurane and isoflurane groups, which was statistically significant compared with halothane group.This study shows that halothane, enflurane and isoflurane has no hamful effects on the postoperative hepatic functions, when they are administered in the pediatric patients with normal preoperative hepatic funcions.
