Studies on Antiinflammatory and Immune Effects of Triptophenolide
- VernacularTitle:雷酚内酯的抗炎免疫药理作用
- Author:
Jun YANG
;
Dongfang YU
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Triptophenolide (TN) is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. It can obviously inhibit the edema caused by xylol and mixture croton oil; and decrease the concentration of Vitamin C in the adrenal gland of mice.TN can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc.Moreover, TN can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro. TN can promote the phagocytosis of macrophages at the small dosage, but at larger dosage, it showed inhibition.The results mentioned above showed that triptophenolide may be one of the main effective component of T.wilfordii for treating auto-immune diseases.
