Effect of Ginseng and Angelica Sinensis Decoction(GASD) on Learning and Memory of Dementia Rat with Hippocampal Lesions Induced by Quinolinic Acid
- VernacularTitle:参归煎剂对喹啉酸损毁海马所致痴呆大鼠学习记忆的影响
- Author:
Qinglin SONG
;
Ruiyi ZONG
;
Xianglin XIE
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
By one trial passive avoidance respense-step-down task and water maze spatial localizat ion task, the effect of Ginseng and Angelica Sinensis Decotion (GASD)on pathological mod els of the anmesia rat with hippocampal lesions induced by quiuolinic acid was studied. Re sults suggest that GASD can improve learning aud memory deficiency in rats with bilateral hippocampal lesions after administration of quinolinic acid. The major mechanism of GASD may be related to the regulation of the glutamatergic fuuction and prevention of the neuro toxicity of quinolinic acid
