Effects of Emodin and Rhubarb Polysaccharides on the Cytoplasmic Free Calcium in the Spleen Lymphocytes of Mice
- VernacularTitle:大黄素和大黄多糖对小鼠脾淋巴细胞内游离钙浓度的影响
- Author:
Zhuhua JIN
;
Xiuzhen LIN
;
Delu MA
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of emodin and rhubarb polysaccharides on the cytoplasmic free calcium in Iymphocyte of mice were studied with the latest generation fluorescent indicator Fura-2. Resultsshowed that emodin at a final concentration of 18.5 ?mol/L promotes the influx of extracellular ca2+ of lympbocytes. Polysaccharides inhibit the influx of Ca2+ aud the release of Ca2+from intracellular stores and their effects are dose dependent. Therefore, it suggests thatemodin can improve the immune function of spleen lymphocytes, but the polysaccharides caninhibit their function. This may be ouc of the theoretical evidences of the biphasic regulationeffects of rhubarb.
