Protective Effects of Sophoramine on Acute Myocardial Infarction and Reperfusion Injury in Conscious Rats
- VernacularTitle:槐胺碱对清醒大鼠心肌急性梗塞及再灌注损伤的保护作用
- Author:
Ying JIN
;
Xiaodong WANG
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of sophoramine (SA) on myocardial infarction size and ischemia－induced and reperfusion－induced arrhythmia were studied in conscious rats. It was found that pretreatment with SA 13.3 and 15 mg/kg iv reduced significantly infarct size and cardiac LDH release at 6h afte left descending coronary artery ligation as compared with the control. SA 10.6, 13.3 and 15mg/kg iv decreased markedly the early ischemic arrhythmia in conscious rats. Amiodarone 7.5mg?kg－1 had the same effects on the prevention of ischemic arrhythmia. In reperfusion experiment,it decreased the incidence of ventricalar fibrillation and significantly shortened the duration of arrhythmias. These results suggest that SA has protective effects on myocardial ischemia and reperfusion injury.
