Protective Effect of Paeonol Against Ischemia Reperfusion Damage in Cardiac Mitochondria Membrane of Rats
- VernacularTitle:丹皮酚对大鼠心肌缺血再灌注损伤的线粒体膜脂的保护作用
- Author:
Weiguo ZHANG
;
Zhishan ZHANG
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
60mg /kg?d ip, of paeonol were given to rats for 15 days. The myocardial ischemia reperfusion injury model was produced by occluding the left coronary artery and releasing the occlusion in rats. This significantly decreased myocardial Ca++-ATPase activitics and CH/PL radical, FFA content, improved mitochondrial membrane fluidity and kept them away from oxygen free radical damage. These results indicated that paeonol has membrane protective effect on myocardial ischemia rcperfusion injury probably by inhibiting the oxygen free radicals and subsequent lipid peroxidation.
