Effects of ″Suxiaojiuxin pill" on Isolated Rabbit Aortic Stripes
- VernacularTitle:速效救心丸对兔离体主动脉条的作用
- Author:
Lianfa ZHOU
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Suxiaojiuxin pill" at a dose of 2mg/ml obviously inhibited the contraction of isolated rabbit aortic stripes induced by high K+, NA, Ach, His and 5-HT. In comparison with phentolamine, the "pill" did not shift the dose-response curve of NA, but depressed maximum response in a none competititve manner. However, similar to verapamil, it shifted high K+and Ca++-free high K+ dose response curve to the right at doses of 0.2~0.4mg/ml. PEG as a solvent did not show any effect in the all tests. These results indicated that "Suxiaojiuxin pill" has a Ca++ antagonistic effect in a none competitive manner, mainly by blocking Ca++entry through the potential dependant channel though at high concentrations it may also influenced the NA activated receptor operated channel (ROC ),
