Screening for NGF Active Chinese Medicinal Herbs and Their Active Components
- VernacularTitle:神经生长因子受体活性中草药及其成分的筛选
- Author:
Liming JIANG
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
It has been revealed that nerve growth factor (NGF ) deficiency is the main cause of some kinds of neuron degenerative diseases such as Alzheimer's disease, and NGF administration can protect neuronal function decay and promote nerve regeneration. Moreover,NGF actions are mediated by its receptors. In the present study, 125I-NGF receptor binding assay was used as a model for the screening of NGF receptor active components from 14 Chinese medicinal herbs. It was found that a component from the root of Achyranthes bidentata BI. possesses such inhibitory activity with IC50 = 6. 18? 3.43 ?g/ml.
