COMPARATIVE STUDY ON THE STRUCTURAL CHARACTERISTICS OF MICROFILAMENTS IN CELLS WITH DIFFERENT METASTATIC ABILITY CLONED FROM HUMAN GASTRIC CANCER CELL LINE BGC-823
- VernacularTitle:人胃癌细胞系BGC—823不同转移能力的细胞克隆间的细胞微丝结构特征研究
- Author:
Rui LU
;
Yang KE
;
Guirong LU
;
Tao NING
;
Weili LIU
;
Jing LIAO
;
Bing WANG
;
Zheng EH
- Publication Type:Journal Article
- Keywords:
Cell line BGC-823;
Metastasis;
Microfilament;
Microvilli
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Ten cell strains were obtained from the human gastric cancer cell line BGC-823 by using the method of single cell cloning. Through inoculation of these cell strains in nude mice and subsequent observation of their metastatic capability, four cell lines, C_1, C_6 with high, and C_5, C_8 with low metastatic capability were selected out; and their biological and morphological properties were studied. It was demonstrated that all of them did not show apparent difference in growth ability, but morphologically, the mictovilli of C_5 and C_8 cells were scarce and short; and their microfilaments were thick, straight and well organized. Whereas the microvilli of C_1 and C_6 strains were long and abundant comparatively, but their microfilaments were poorly organized. On the basis of present observation,we suggested that the organization of microfilaments in cancer cells appeared to bear reversed relationship with their metastatic capability.
