RELATIONSHIP BETWEEN ENKEPHALIN-IMMUNOREACTIVE TERMINALS AND OXYTOCIN-OR VASOPRESSIN-CONTAININGCELLS OF THE HYPOTHALAMUS IN THE RAT
- VernacularTitle:大鼠下丘脑催产素及加压素样神经元与脑啡肽样传入纤维末梢的关系
- Author:
Xiaoqin DUAN
;
Gong JU
- Publication Type:Journal Article
- Keywords:
Hypothalamus;
Enkephalin;
Oxytocin;
Vasopressin;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Double immunohistochemistry staining method was used to visualize Leu-and Met-enkephalin-immunoreactive(L-ENK-ir and M-ENK-ir) terminals on oxytocin (OT)- and vasopressin(VP)-containing cells and their processes of the rat hypothalamus. The L-ENK-ir and M-ENK-ir nerve endings were found in various density in the supraoptic nucleus(SON), the paraventricular nucleus(PVN) and each of the accessory neurosecretory cell groups of the hypothalamus. The density of the L-ENK-ir endings paralleled to, but always higher than that of the M-ENK-ir terminals in the magnocellular neurosecretory cell groups. The density of the L-ENK-ir and M-ENK-ir endings was highest in the periventricular area(PeV), the anterior commissural nucleus(ACN), the dorsal medial and dorsal lateral accessory nuclei (DMN and DLN), the anterior and posterior fornical nuclei(AFN and PFN), moderate in the SON and PVN, and lowest in the nucleus circularis (NC) and the lateral hypothalamic perivascular nuclei(LHPVN). In all the cell groups, the L-ENK-ir and M-ENK-ir terminals which were found in contact with the OT- and VP-containing cells and dendrites were consistant with the density of the endings in the same area. These results indicate that ENK-ir afferents may be in extensive contact with the OT-and VP-containing cells and dendrites in the SON, PVN and the accessory magnocellular neurosecretory cell groups of the hypothalamus. These ENK-ir afferents probably play an important role in the regulation of the secretion of OT and VP.
