Study on Dissolution Rate of Silymarin(Yiganling) Tablets Ⅰ.Dissolution Investigation of Silymarin and Its Solid Dispersion Tablets
- VernacularTitle:水飞蓟素(益肝灵)片剂溶出速度的研究——水飞蓟素及其固体分散物片剂溶出考察
- Author:
Dawei CHEN
;
Xingcan CHEN
- Publication Type:Journal Article
- Keywords:
dissolution rate, Silymarin (Yiganling) Tablets,silymarin PEG fusion, PVP coprecipitation, ?-CD inclusion compound.
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The dissolution rates of Yiganling Tablets produced by 6 pharmaceutical factories of China and Liganlong Tablets by MAOAUS Factory in German were investigated. As a result, after 30min, the dissolution of all Yiganling is below 30％ and that of Liganlong is 50%. After 120min, the largest dissolution of the former isn't over 43%, and that of the later is about 55％, which indicates that silymarin tablets dissolve more slowly and their bioavailability is lower. The dissolubility can be raised 37, 60 and 27 times, respectively if the silymarin was made into PEG fusion) PVP coprecipitation or ?-CD inclusion compound. The disolution rate (T_(50)) of correspording tablets are 14, 11 and 20min. The largest dissolution after 120min reaches about 80%-103％. There isn't any change observed in the structure of silymarin in solid dispersion when it was identified with UV, IR and TLC. The micropolariscope photograph shows the crystal degree decreased and the dispersity increased.
