THE DISTRIBUTION OF LARGE GRANULAR VESICLES IN SUBSTANCE P AXON TERMINALS AND THEIR SYNAPTIC RELATIONS IN THE TRIGEMINAL SUBNUCLEUS CAUDALIS
- VernacularTitle:三叉神经脊束核尾侧亚核P物质轴突终末的大颗粒小泡分布特点和突触联系
- Author:
Ziyue LU
;
Peichun ZHU
;
Haixia WU
;
Hong XU
;
Enfa REN
;
Dianhua JIANG
- Publication Type:Journal Article
- Keywords:
Substance P;
Large granular vesicles;
Synapse;
Trigeminal subnucleus caudalis;
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The ultrastructural localization of substance P (SP) immunoreactivity, especially the morphology, number and distribution of positive large granular vesicles (LGV) in SP axon terminals of the trigeminal subnucleus caudalis of the rat were studied by electron microscopic immunocytochemistry. This study revealed that SP immunoreactivity was mostly located in axon terminals and unmyelinated fibers. SP axon terminals contained both clear round vesicles and LGV. SP immunoreactivity was found in LGV, and on the surface of clear round vesicles and outer membrane of mitochondria. Positive LGV were spherical or oval in shape (60～120nm in diameter). The number of LGv was mostly 2～3 in a SP axon terminal. LGV often apposed to the axolemma or scattered in the centre of terminal. LGV were far from the presynaptic sites of the SP terminals which formed synapses. The number of LGV closed to the terminal membrane was significantly (P
