A STUDY ON QUANTITATIVE ALTERATION OF 5srRNA DURING THE DEVELOPMENT OF MAMMALIAN ERYTHROCYTES
- VernacularTitle:哺乳类动物红细胞发育分化过程中5srRNA相对量变化的研究
- Author:
Yan XU
;
Xue HU
;
Jin TANG
;
Ruoming YANG
;
Shepu XUE
- Publication Type:Journal Article
- Keywords:
5srRNA;
DNA synthesis;
Denucleation;
Cancer cells reversion
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study reported that 5srRNA from reticulocytes of rabbit could pass into the nucleus of mouse myeloma cells SP2/0,and in the mean time DNA synthesis and cells division were markedly suppressed. In a separate experiment, the rRNA was extracted from embryonic liver and erythrocytes of rabbit or rat and analysed by agarose electrophoresis method. The result indicated that the amount of 5srRNA in various period of the development of erythrocyte is changed along with denucleation process. Thus it is likely that 5srRNA of mammalian erythrocyte plays a role in reversing malignant phenotype of tumor cells and promoting denucleation of mammalian erythrocyte through inhibiting DNA synthesis.
