THE DISTRIBUTION OF NK CELLS IN THE HUMAN LYMPHOID ORGANS
- VernacularTitle:自然杀伤细胞在人淋巴器官内的分布
- Author:
Zhenhua GE
;
Ruoyu WANG
;
Jijin WAN
- Publication Type:Journal Article
- Keywords:
Natural killer cells;
Immunohistichemistry;
Lymphoid organs;
Human
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Leu 7 monoclonal antibody and immunohistochemical technic were used to study the distribution of NK cells in human lymph node, tonsil, spleen and thymus. The results indicated that the NK cells predominately distributed in B cell area, such as germinal center of secondary follicle, which occured in lymph node and tonsil. A few NK cells were found in the paracortex and medulla of lymph node. In the spleen, the NK cells mainly located in the germinal center of splenic nodules and in the periphery of white pulp. However, the NK cells were never shown in the perarterial lymphatic sheath, some NK cells also scattered in the pulp cord and sinuses of red pulp. In the thymus, the NK cells were restricted in the medulla, and the number of NK cells reduced in the aged thymus. In addition, the Leu 7 antibody was reacted with epithelial cells, which located in the cortical periphery or thymic lobule. The morphology of NK cells in different lymphoid organs was similar. The staining intensity of Leu 7 antibody was identical both in the frozen and paraffin sections.
