IMMUNOHISTOCHEMICAL STUDY OF REGULATORY PEPTIDES IN HUMAN PLACENTALVILLA
- VernacularTitle:人胎盘绒毛调节肽的免疫组织化学研究
- Author:
Weiquan HUANG
;
Chongli ZHANG
;
Hong WANG
- Publication Type:Journal Article
- Keywords:
GnRH;
Somatostatin(SS);
?-Endorphin(?-EP);
Immunohistochemistry;
Human placenta
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Localization and quantitation of GnRH, somatostatin (SS), and ?-endorphin (?-EP) in human placentalvilla were studied using immunogold-silver staining method. GnRH and SS immunoreactive positive substance existed in the cytotrophoblasts of many placental villi and in syncytiotrophoblasts of few placental villi, ?-EP immunoreactive positive substance localized in syncytiotrophoblasts of many placental villi and in cytotrophoblasts of few placental villi. These results suggest that the cytotrophoblasts and syncytiotrophoblasts are able to synthesize these three kinds of regulatory peptides, however, SS and GnRH may be synthesized mainly in the cytotrophoblasts, ?-EP mainly be synthesized in the syncytiotrophoblasts. The amount of GnRH and ?-EP in placenta villi show obvious change with progress of pregnancy. This change show a negative relationship between the GnRH and ?-EP, which suggested that there may be a functional reciprocal inhibition between the GnRH and ?-EP.
