ROLE OF LYSOSOMES IN THE DEVELOPMENT OF EXPERIMENTAL CARDIAC HYPERTROPHY
- VernacularTitle:溶酶体在实验性心肌肥大过程中的作用
- Author:
Xiaogang ZHENG
;
Xueming TANG
;
Yusheng HAN
;
Yuying CHEN
- Publication Type:Journal Article
- Keywords:
Experimental cardiac hypertrophy;
Lysosome;
Autophagocytosis;
Electron microscopy;
Rats
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In present study, animal model of cardiac hypertrophy induced by abdominal aortic stenosis was utilized, and the lysosomes were investigated by electron microscopy and ultrastructural cytochemistry. The results showed that while cardiac hypertrophy developed, lysosomes participate in apparent remolding of cardiac muscle cells; in the late stage of cardiac hypertrophy, a great deal of autophagocytoses were viewed in some muscle cells which may result in irreversible cell damage.
