THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE
- VernacularTitle:链脲霉素糖尿病小鼠外周血T淋巴细胞数量和腹腔巨噬细胞吞噬功能研究
- Author:
Qifu LI
- Publication Type:Journal Article
- Keywords:
Diabetes Mellitus;
T lymphocyte;
Macrophages;
Streptozotocin
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The peripheral T-lymphocyte number and phagocytic function of peritoneal macro-phages were studied in diabetic C57 mice induced by streptozotocin.. No significant difference in the peripheral lymphcyte number was found, but the percentage of T-lymphocytes quantitated by ANAE staining significantly decreased in diabetic mice. The phagocytic activity of yeasts by peritoneal macrophages was apparently lower in diabetic mice than in normal control. The decrease of T-lymphocytes and depressed phagocytosis of macrophages suggest impaired function of cell-mediated immunity in streptozotocin-induced diabetic mice
