STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE
- VernacularTitle:腹腔巨噬细胞培养上清液对小鼠红系造血调控的研究
- Author:
Bide ZHU
- Publication Type:Journal Article
- Keywords:
Macrophage;
BFU-E;
CFU-E;
E rythropoiesis;
Erythropoietin;
BPA
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of cultured supernatants of non-stimulated and LPS-induced peritoneal macrophages on erythropoiesis in C57BL/6J mice was studied by using the techniques of culture of hemopoietic progenitor cells in vitro. Our results indicate that(l)BFU-E growth is enhanced significantly after addition of either non-stimulated or LPS-induced supernatants of peritoneal macrophages; (2) the supernatants present positive and negative feedback control on CFU-E, growth-low concentration supernatants stimulate CFU-E and high concentration supernatants present inhibition; (3) the LPS-induced supernatants of peritoneal macrophage show stronger activities than non-stimulated supernatants to the proliteration of both BFU-E and CFU-E and(4)the supernatants of the cultured peritoneal macrophage may contain EPO-like, BPA-like stimulating activities, which regulate the proliferation of both BFU-E and CFU-E
