Taxol and Taurine Protect the Renal Tissue of Rats after Unilateral Ureteral Obstruction: A Stereological Survey.
10.4111/kju.2012.53.5.360
- Author:
Saied KARBALAY-DOUST
1
;
Ali NOORAFSHAN
;
Seyed Mohammad POURSHAHID
Author Information
1. Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. noora@sums.ac.ir
- Publication Type:Original Article
- Keywords:
Kidney;
Stereology;
Taurine;
Taxol;
Ureteral obstruction
- MeSH:
Animals;
Atrophy;
Cell Death;
Dilatation;
Fibrosis;
Kidney;
Paclitaxel;
Rats;
Taurine;
Ureter;
Ureteral Obstruction;
Urinary Tract;
Water
- From:Korean Journal of Urology
2012;53(5):360-367
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Blockage of the urinary tract induces changes in renal structure including tubular dilatation or atrophy, tubular cell death, inflammatory processes, and progressive interstitial fibrosis with the loss of renal parenchyma. The present study was conducted to survey the protective effects of Taxol and taurine on the renal structure after unilateral ureteral obstruction (UUO). MATERIALS AND METHODS: UUO was induced in three groups of rats (n=6) who then received distilled water, Taxol (0.3 mg/kg/d), or taurine (7.5 mg/kg/d). Stereological methods were used to gather quantitative as well as comparative data. RESULTS: Less than -8% of the volume of the glomeruli, proximal convoluted tubules (PCT), distal convoluted tubules (DCT), Henle's loop, and collecting ducts were preserved after UUO. After treatment of the UUO rats with Taxol, between -32% and 88% of the parameters mentioned above remained intact, and after treatment of the UUO rats with taurine, between -16% and 46% of the parameters remained intact (p<0.01). Compared with the untreated UUO animals, the volume of necrotic and fibrotic tissues decreased -53% and -63% in the UUO rats treated with Taxol and taurine, respectively (p<0.01). Less than -3% of the lengths of the renal tubules (PCT, DCT, Henle's loop, and collecting) were preserved in the UUO rats. After treatment with Taxol and taurine, -61% to 70% and -43% to 53% of the length of the renal tubules were preserved, respectively (p<0.01). CONCLUSIONS: Taurine and Taxol are effective in preventing some structural renal damage in a direct ureteral obstruction model. Taxol was more effective in renal protection.
