DETERMINATION AND CLINICAL SIGNIFICANCE OF CONCENTRATIONS OF PLASMA AMMONIA, SERUM TRYPTOPHAN, SEROTONIN AND 5-HYDROXYINDOLACETIC ACID IN PATIENTS WITH HEPATIC ENCEPHALOPATHY
- VernacularTitle:肝性脑病患者血氨、血清色氨酸、5-羟色胺及5-羟吲哚乙酸的测定
- Author:
Shilin YI
;
Baoyuan XU
- Publication Type:Journal Article
- Keywords:
hepatic encephalopathy;
ammonia;
tryptophan;
serotonin;
5-hydroxyin-dolacetic acid
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Our study showed that the concentration of plasma ammonia in patients with hepatic encephalopathy was increased significantly than that in patients with decompensated liver cirrhosis, primary hepatocellular carcinoma and fulminant hepatitis. The concentration of serum free tryptophan and "free/total" tryptophan ratio in patients with hepatic encepha-lopathy were significantly increased as compared with patients of other three groups. The concentration of serum serotonin was not significantly increased and that of serum 5-hy- droxyindolacetic acid was significantly increased in comparison with normal controls. In addition, the concentrations of serum free tryptophan and serum "free/total" ratio were closely positive correlated with the degree of hepatic encephalopathy, the concentrations of. plasma ammonia and serum free tryptophan and serum "free/total" ratio were higher in patients with hepatic coma than that of patients regainning consciousness, but the difference was not statistically significant. The role of plasma ammonia and serum tryptophan in pathogenesis of hepatic encephalopathy was discussed
