AUTORADIOGRAPHIC OBSERVATION OF GOSSYPOL EFFECT ON REABSORPTION AND EXCRETION OF ~(42)KCL IN THE RENAL TUBULES
- VernacularTitle:用放射自显影术观察棉酚对肾小管重吸收及转运~(42)K功能的影响
- Author:
Kequan CHEN
;
Leying ZHANG
;
Jin TANG
;
Shepu XUE
- Publication Type:Journal Article
- Keywords:
Gossypol;
Autoradiography;
Gentamicin;
~(42)K;
Renal tubules
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study was designed to investigate the effect of gossypol on the reabsorption and excretion of ~(42)K in rats and guinea pigs by using autoradiographic technique, and selected the well known tubulo-toxic agent, gentamicin as a positive control for a comparative study to evaluate whether gossypol exerts nephrotoxic effect. Our results confirmed that gentamicin could induce significant decrease or inhibit ~(42)K reabsorption and cause structural damage of renal tubules. Gossypol could also affect the reabsorption function of proximal tubule, but did not appear to act as a tubulotoxic agent comparable with gentamicin to cause injury of the renal tubules.
